Neuroprotective and MAOB inhibitory effects of a series of caffeine-8-thioglycolic acid amides
نویسندگان
چکیده
منابع مشابه
Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid.
The synthesis of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid was studied. The structures of synthesized compounds were proved by micro-analyses, IR- and 1H NMR data. Values of acute p.o. and i.p. toxicity in mice show lower toxicity compared to caffeine. Declines in spontaneous locomotor activity support the idea of depressive CNS activity of the compounds. Two compo...
متن کاملSynthesis and Brain Antihypoxic Activity of Some Aminoalcoholic Derivatives of Caffeine-8-thioglycolic Acid
The synthesis and pharmacological activity of some aminoalcoholic derivatives of 8-caffeinethioglycolic acid was studied. The structure of the synthesized compounds was proved by microanalysis, IRand H-NMR spectra. All of the investigated compounds were found to be practically non-toxic (LD50 p.o. > 5 g kg in mice) and less toxic compared to caffeine. The compounds were investigated for antihyp...
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ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2020
ISSN: 2175-9790
DOI: 10.1590/s2175-97902019000318255